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M9550827.TXT
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1995-03-25
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Document 0827
DOCN M9550827
TI The effects of adrenocorticotropic hormone and heat stress on the
distribution of lymphocyte populations in immature male chickens.
DT 9505
AU Trout JM; Mashaly MM; Department of Poultry Science, Pennsylvania State
University,; University Park 16802.
SO Poult Sci. 1994 Nov;73(11):1694-8. Unique Identifier : AIDSLINE
MED/95166739
AB This study investigated the effects of heat stress and
adrenocorticotropic hormone (ACTH) on the distribution of lymphocyte
populations. Two experiments were conducted; each used 12-wk-old Cornell
K-strain male chickens. In Experiment 1, birds were exposed to a
temperature of 35 C, 6 h/d for 5 d and control birds were maintained at
24 C. In Experiment 2, birds received daily i.m. injections of 50 IU/kg
body weight of ACTH for 5 d and control birds received .9% saline. On
Day 6, blood and spleens were collected and lymphocytes were isolated.
Indirect immunofluorescent labeling of lymphocytes were performed to
detect B lymphocytes, CD4+ cells, and CD8+ cells. Neither ACTH injection
nor heat stress affected percentages of B lymphocytes in the blood or
the spleen. The CD4+ cells decreased significantly in the blood of
ACTH-injected and heat-stressed birds and significantly increased in the
spleens of heat-stressed birds. The CD4+ cells in the spleens of
ACTH-injected birds did not differ from controls. The CD8+ cells
significantly declined in the blood following both ACTH injection and
heat stress and significantly increased in the spleen of the
ACTH-injected birds but did not differ from controls in the
heat-stressed birds. These results indicate that stress factors lead to
redistribution of different lymphocyte populations.
DE Animal Chickens/*BLOOD Corticotropin/*ADMINISTRATION & DOSAGE
*CD4-Positive T-Lymphocytes *CD8-Positive T-Lymphocytes Heat/*ADVERSE
EFFECTS Injections, Intramuscular Lymphocyte Count Male
Spleen/CYTOLOGY/DRUG EFFECTS Stress JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).